Phenothiazines inhibit SARS-CoV-2 cell entry via a blockade of spike protein binding to neuropilin-1Article Published on 2023-01-012023-07-11 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] COVID-19 Neuropilin-1 phenothiazine SARS-CoV-2. [DOI] 10.1016/j.antiviral.2022.105481 PMC 바로가기
The Elusive Coreceptors for the SARS-CoV-2 Spike ProteinReview Published on 2022-12-252023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] COVID-19 leucine rich repeat containing 15 LRRC15 mutations N-terminal domain Neuropilin-1 NRP-1 receptor binding domain. SARS-CoV-2 [DOI] 10.3390/v15010067 PMC 바로가기 [Article Type] Review
Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent MannerArticle Published on 2022-10-262023-07-10 Journal: Journal of Virology [Category] COVID19(2023년), [키워드] C-end Rule Entry glycoprotein B Neuropilin-1 Pathogenesis Pseudorabies virus virulence. [DOI] 10.1128/jvi.01318-22 PMC 바로가기
Neuropilin-1 in the pathogenesis of preeclampsia, HIV-1, and SARS-CoV-2 infection: A reviewReview Published on 2022-10-022023-07-10 Journal: Virus research [Category] COVID19(2023년), [키워드] HIV-1 infection MicroRNAs Neuropilin-1 preeclampsia SARS-CoV-2 infection. [DOI] 10.1016/j.virusres.2022.198880 PMC 바로가기 [Article Type] Review
Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approachArticle Published on 2022-09-012022-11-15 Journal: Microbial pathogenesis [Category] SARS, 유전자 메커니즘, 치료제, [키워드] addition African Analysis Antiviral compound antiviral target approach binding energy calculate Cell cellular entry characterized Compound conformational database demonstrated disrupt distribution expressed feature functional In-vitro inhibitory effect Interaction mechanism of action molecular molecular dynamic simulation Molecular dynamics simulation multiple organ natural natural product Neuropilin-1 NRP1 performed pleiotropic Protein recent S-protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 research screened selected South stability surface receptor the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach viral infectivity virtual screening. [DOI] 10.1016/j.micpath.2022.105701 PMC 바로가기
In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols’ Potential for Inhibition of SARS-CoV-2 InternalizationAlchemilla viridiflora Rothm-Polyphenols의 SARS-CoV-2 내재화 억제 가능성에 대한 실리코 및 체외 연구Article Published on 2022-08-142022-09-11 Journal: Molecules [Category] SARS, 변종, [키워드] ACE2 Alchemilla viridiflora Rothm. angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents binding binding energy binding interaction Compound computational studies Computational study Contact COVID-19 COVID-19 pandemic dose doses E484K effective Effectiveness exhibited flavonoid G476S glycoprotein Health higher affinity highest in silico in vitro inhibited inhibition internalization investigated K417N methanol molecular docking studies Molecular docking study Mutation N439K N501Y neuropilin Neuropilin-1 NRP1 outbreak plants polyphenols Potential Prevent quercetin receptor receptors resulting SARS-CoV-2 SARS-CoV-2 strain selected significantly spike glycoprotein spike glycoprotein. tested V483A virus virus infection Virus spike wild strain [DOI] 10.3390/molecules27165174 PMC 바로가기 [Article Type] Article
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1ESCPE-1은 SARS-CoV-2 숙주 인자 Neuropilin-1의 역행 엔도솜 분류를 매개합니다Article Published on 2022-06-212022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 bacterial pathogen cargo Cell culture cellular homeostasis characterized complex coronavirus COVID-19 CRISPR-Cas9 develop endosomal endosome exit facilitate Host identify Infection Lipid lipids maintain membrane methodology neuropilin Neuropilin-1 NRP1 Pathogens peptide Protein proteomic reduce SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus sorting nexin. subcellular subunit the SARS-CoV-2 transmembrane protein virus [DOI] 10.1073/pnas.2201980119 PMC 바로가기 [Article Type] Article
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infectionTLR2 및 TLR7은 SARS-CoV-2 감염에 대한 뚜렷한 면역병리학적 및 항바이러스 형질세포양 수지상 세포 반응을 매개합니다Article Published on 2022-05-162022-09-12 Journal: The EMBO Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Antiviral antiviral interferon circulating COVID-19 patient Critical CXCL10 cytokine de novo decreased expression dendritic cell disease severity driving engage epithelial cell identify IFNs IFNα IL-6 IL-8 immunopathological in vitro Inflammatory Inflammatory response innate immune innate immune pathways innate immune sensing interferon response mitigate molecular Neuropilin-1 pathway pDC pDC. pDCs plasmacytoid dendritic cell potential therapeutic target PROTECT receptor response responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe COVID-19 Signaling symptom onset systemic inflammatory TLR2 TLR7 Treatment type I understanding Via virus [DOI] 10.15252/embj.2021109622 PMC 바로가기 [Article Type] Article
Neuropilin-1-Mediated SARS-CoV-2 Infection in Bone Marrow-Derived Macrophages Inhibits Osteoclast Differentiation골수 유래 대식세포의 뉴로필린-1 매개 SARS-CoV-2 감염은 파골세포 분화를 억제합니다Article Published on 2022-05-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysis angiotensin angiotensin-converting enzyme 2 B.1.351 bone Bone marrow bone marrow-derived macrophages calcium Clinical data Cluster Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients damage dependent on differentiation Evidence expression host cell host cells Human skeleton humans identify impede in vivo Infection inhibit SARS-CoV-2 Interaction investigated knockdown macrophages marrow-derived macrophage metabolism mouse model Mouse models neuropilin Neuropilin-1 neutralization NRP1 organs osteoclast osteoclast differentiation Pathogenesis pathogenesis of SARS-CoV-2 patients phosphorus phosphorus metabolism provide receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe acute respiratory syndrome coronavirus 2. significantly Single-cell RNA sequencing susceptible tissue tropism various tissue various tissues virus wild-type [DOI] 10.1002/adbi.202200007 PMC 바로가기 [Article Type] Article
Ferristatin II Efficiently Inhibits SARS-CoV-2 Replication in Vero CellsBrief Report Published on 2022-02-032022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS, [키워드] A significant reduction ACE2 acute respiratory syndrome affected block CD147 Cell Concentration confocal microscopy consequence coronavirus COVID-19 Culture D614G Degradation Delta demonstrated distribution domain ferristatin II global public health host cells induce Infection inhibited mechanism medium Multiple Neuropilin-1 non-toxic omicron Protein RBD RBD protein receptor Receptor-binding domain (RBD) replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 host cell SARS-COV-2 infection SARS-CoV-2 receptors SARS-CoV-2 variant significantly spike the SARS-CoV-2 therapeutic strategy Transferrin transferrin receptor 1 Treatment Vero Vero Cell Vero cells viability viral entry virus virus inhibition Wuhan [DOI] 10.3390/v14020317 PMC 바로가기 [Article Type] Brief Report